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The FLOW trial notably demonstrated a reduction in the risk of major adverse cardiovascular events, death from cardiovascular causes and all-cause mortality with semaglutide in adults with CKD and T2D, with prespecified analyses suggesting that these outcomes were consistent in patients across BMI groups and with/without prior SGLT2i use [9]

The data on insulin secretion, insulin sensitivity, and glucose homeostasis were confirmed in the phase II clinical study (clinical trials registration number NCT03131687) (62)

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