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It has high potency for GH release in vitro and in vivo, with minimal stimulation of cortisol or ACTH, thereby helping to avoid many side effects commonly associated with less specific GH secretagogues

Evidence-based treatment

Fortunately, there are supportive strategies to help manage these symptoms

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Procedures including Roux-en-Y gastric bypass, sleeve gastrectomy, and adjustable gastric banding produce 20-35% total body weight loss and significant improvement in obesity-related comorbidities including type 2 diabetes, hypertension, and obstructive sleep apnea