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Furthermore, a recent 2026 report from risk consulting firm Aon suggested that workers sustained GLP-1 use can reduce employers costs over time

most effects persist at 1 year, including a significant reduction in shunt placement (OR 0.375)

The reason: prolonged continuous exposure downregulates IGF-1 receptor density (receptor desensitization)

In addition, blood levels of other markers possibly associated with cardiovascular disease, such as glucose, cholesterol, triglycerides and C-reactive protein (a marker of inflammation), were also measured

No serious adverse reactions were reported [8]