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The agitation introduces air bubbles that create foam, and the foam-liquid interfaces generate shear stress that denatures the protein

This engineered system demonstrates suitable particle size and excellent biocompatibility, while offering optimal release of methotrexate induced by cold temperatures

Mitochondrial function was severely compromised on multiple levels, including abnormalities in mitochondrial biogenesis (PGC1), nutrient sensors regulating fatty-acid entry into mitochondria (pAMPK/AMPK, SirT3, CPT1b), mitochondrial -oxidation of fatty-acids (HADHA, PPAR), electron transport chain complexes (I, II, III, V), ATP synthesis (ATP5A), and mitophagy (PINK1)

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A type of endemic cardiomyopathy, Keshan disease is linked to selenium deficiency 8,11