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Mounjaro and Zepbound contain terzepatide, which works as a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist

This result was replicated by long-term in vitro exposure of pancreatic islets from diabetic rats to PYY

The Cons: Small molecules are metabolized by the liver (unlike peptides, which break down into amino acids)

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primarily through a 39% reduction in stroke risk