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Kaur G., Singh A., Arora G., et al., Synthetic Heterocyclic Derivatives as Promising Xanthine Oxidase Inhibitors: An Overview, Chemical Biology & Drug Design 100 (2022): 443468, 10.1111/cbdd.14109

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Main text Role of oxidative stress in ALS ALS is an adult-onset neurodegenerative disease, characterized by degeneration and loss of upper motor neurons (MNs) in the cerebral cortex and lower MNs in the brainstem and spinal cord [69], leading to progressive weakness of voluntary muscles, and death caused by a diaphragmatic failure within 25 years [70, 71]

Some practitioners use subcutaneous injections of 200 to 300 mcg once or twice daily, injected into abdominal subcutaneous tissue near the area of concern

Diabetes Care (2018) 41(12):2669701