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Can be irritating Used as a fragrance A plant root extract that helps attract water to the upper layer of the skin

Topical vs Injectable Tolerability Topical GHK-Cu appears better tolerated than injectable forms, with topical side effects typically limited to mild redness, itching, or irritation at application site and rare copper uglies phenomenon (anecdotal accelerated skin aging appearance due to potential MMP upregulation, not well-studied)

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High doses significantly increased this side-effect profile: 77% experienced adverse GI effects which caused a significant amount of patients to drop out of the studies

In the context of PD, the event of reaching a 5-point worsening in MDS-UPDRS Part III signifies a tangible decline in motor function 17 , often translating to noticeable difficulties in daily activities and a reduced quality of life