The nitric oxide generated through this pathway promotes vasodilation, inhibits platelet aggregation, and enhances endothelial cell survival while supporting the formation of patent, functional vessels
For example: Bacopa monnieri (an Ayurvedic herb) has been reported to slightly improve memory acquisition and the speed of attention in chronic use
Additionally, there are drug efflux pumps such as p -glycoprotein (P-gp), multidrug resistance associated protein (MRP) and drug metabolic enzymes, at the BBB to remove and/or inactivate small drug molecules from the brain [1]
Nuclear receptor cofactor 4 (NCOA4) is a selective cargo receptor for ferritin phagocytosis, i.e., catabolism of ferritin by autophagy, and overexpression of NCOA4 increases ferritin catabolism and promotes ferroptosis (37)
10.5455/msm.2016.28.104-107 10