retatrutide triple hormone receptor agonist benefits Efficacy and safety of retatrutide, a GIP, GLP-1, and glucagon agonist, in people with type 2 diabetes and inadequate glycaemic control with diet and exercise (TRANSCEND-T2D-1): a double-blind, randomised, phase 3 TRIUMPH-4. Retatrutide. A once-weekly triple

Learn more: Saxenda dosage: Finding the right dose for weight loss Saxenda can have side effects that need to be monitored Like other GLP1 medications, Saxenda can cause side effects, especially when the dose is increased

The trade-off is that it requires a prescription and medical oversight

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Nausea was reported in a significant proportion of participants, particularly during the dose-escalation period (Jastreboff et al., 2023)

Chevalier C, Stojanovi O, Colin DJ, Suarez-Zamorano N, Tarallo V, Veyrat-Durebex C et al (2015) Gut microbiota orchestrates energy homeostasis during cold