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Some research protocols involve titrating the dose up after an initial introductory period to find the optimal effective dose for the specific model

Jpn Pharmacol Ther 2018;46:561580.

And the comparison between peptides and SARMs helps researchers distinguish between fundamentally different classes of research compounds

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Some of the physiological parameters at the first measurement(s) were probably affected by the fact that many children were restless or even frightened at the beginning of the examination because of the procedures in the unfamiliar environment and being surrounded by unfamiliar people (a common observation even outside the study)