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Distant metastases, most commonly to the lungs, liver, and bones, occur in approximately 4050% of patients and are a major cause of mortality (Widemann & Italiano, 2018)

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Therefore, the identification of new drugs for this disease is indispensable

Other symptoms of liver failure include: unexplained nausea or vomiting loss of appetite yellow skin, nails, or eyes (jaundice) itching retaining fluid swollen ankles exhaustion diarrhea Some people are more susceptible to liver failure than others

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