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Overview of Tirzepatide and Retatrutide In the context of tirzepatide vs retatrutide, tirzepatide, marketed under the brand name Zepbound, is a dual agonist that targets both the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors

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As of this writing, retatrutide is in late-stage clinical trials but has not received FDA approval