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43,44 The two SURMOUNT studies provide valuable comparisons since they share a similar duration and involve participant populations that are comparable, with the primary distinction being the presence or absence of T2D among participants

The dose is taken with food containing at least 20 grams of fat to optimize absorption, as isotretinoin bioavailability doubles with a high-fat meal [3]

Finally, bypassing concerns with an upset stomach while providing greater quantities of medicine for a more potent impact with fewer side effects, the straight bloodstream route is preferred