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Since isolated primary human islets cannot be cultured for extensive periods of time and exhibit donor-to-donor variability, most groups have historically relied on rodent models and cell lines to robustly understand the genetic and mechanistic components involved in the initiation and progression of T1D

Decade-long leukaemia remissions with persistence of CD4(+) CAR T cells

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Monitoring focuses on IGF-1, glucose handling, lipids, thyroid context, appetite, and fluid-retention symptoms