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Harvey CJ, Thimmulappa RK, Sethi S, et al

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Studies have also revealed a relationship between poor sleep quality and HPA activation, which usually results in cortisol production

R., Hankey, B

The etiology of depression remains unclear to date, and there are various hypotheses regarding the pathogenesis of depression in clinical practice, including the monoamine neurotransmitter hypothesis, the hypothalamicpituitaryadrenal (HPA) axis dysregulation hypothesis, the inflammatory cytokine hypothesis, and the neurotrophic factor hypothesis