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To estimate how the peptide levels during the first 12 months were associated with the fasting C-peptide/glucose ratio at 24 months, a linear slope for each peptide and each individual over the first four visits was calculated using linear regression models

Clinical diagnosis of organic acid metabolism disorders can be assisted by gas-liquid chromatography examination of organic acids and their derivatives in urine and blood, and other auxiliary diagnostic methods include electroencephalogram, cranial nuclear magnetic resonance, enzyme analysis, and genetic testing, etc

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Quantification and statistical analysis Data were analysed with Prism software (GraphPad)

If you ask them, ‘Does it keep you up at night?&rsquo