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Giannetti has received research funding and consulting fees from Blueprint Medicines and consulting fees from Cogent Biosciences

The three GPX4 inhibitors displayed senolytic activity in SK-MEL-103 cells in which senescence had been induced by either etoposide, tozasertib or palbociclib treatment (Fig

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Polymorphisms in the MTHFR gene can reduce enzyme activity, disrupting the folate cycle and leading to hyperhomocysteinemia

Low glutathione levels can manifest through symptoms like fatigue, frequent infections, slow recovery from illness, or signs of oxidative stress such as skin issues or inflammation