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This metabolic profile was associated with mitochondrial dysfunction, lower mitochondrial mass, and increased expression of glycolytic genes, suggesting a distinct immunometabolic phenotype in progressive disease stages

Cell suspensions were serially diluted and plated on TSA with 0.4% activated charcoal (Sigma) to neutralize residual antibiotics, allowing enumeration of surviving bacteria

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Safety signals of special interest, including pancreatitis, gallbladder events, neoplasms, and suicidal ideation, were adjudicated by blinded expert committees