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Once a niche topic in endocrinology, this naturally occurring gut hormone has been thrust into the global spotlight, heralded as a revolutionary tool in the management of type 2 diabetes and, most notably, weight loss

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GPCRs that are agonist-activated promote the synthesis of guanine triphosphate (GTP), which when bound to the G-protein causes the Ga and Gbc subunits to separate, which in turn can activate signaling proteins downstream [52]

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