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Understanding common side effects 1 The most common adverse reactions, reported in 5% of patients treated with RYBELSUS are: nausea diarrhea vomiting abdominal pain decreased appetite constipation nausea abdominal pain diarrhea decreased appetite vomiting constipation In the pool of placebo-controlled trials, the majority of reports of nausea, vomiting, and/or diarrhea occurred during dose escalation

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