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The peptides don't replace the endogenous pulse

575 In the SIRT3 knockout mouse model, the progression of fibrosis and cardiac hypertrophy also accelerated with age

These results are consistent with the major features of hind-limb suspension-related phenotypes of skeletal muscles as an index of anti-gravity muscle atrophy 66 , thus assuring that the experimental design including the mouse age and muscle-disuse period (in vivo assay time-point) were appropriate to the conclusion that 3-days LASSS oral-administration prevents tyrosine-residue nitration of extracellular HGF (Y198) during 5-days muscle disuse

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[DOI] [PubMed] [Google Scholar] 88.Stevens DA