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The NHS and NICE Clinical Knowledge Summaries recommend established treatments with proven efficacy and safety profiles

But in practice, and especially with regard to synthetic and recombinant peptide forms, there are some considerable potential safety concerns: Immunogenicity Most notably, per a 2020 assessment on therapeutic peptide safety, synthetic and recombinant peptides pose the risk of immunogenicity the ability of a substance to provoke an immune response.15 An immunogenicity-inducing peptide, when introduced to the body, would cause the bodys immune system to perceive the peptide not as a medication but as a threat

However, the leap from a mouse model of nerve injury to human treatment of complex neurological conditions is enormous

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It's a mechanical problem and an inflammatory one, all rolled into one