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Specifically, after ligation, in the control rats, the brain damages are widespread, with increased edema and congestion, rapidly and particularly progressing as shown in the cerebral and cerebellar cortex, hypothalamus/thalamus, and hippocampus (Figure 9)

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Abstract Reduced cerebral blood flow (CBF) and cerebrovascular function are critical early-stage biomarkers preceding changes in brain function and structure observed in normal aging and during the onset and progression of Alzheimers Disease and related dementias (ADRD)

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*Correspondence: Xiang Li, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers