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Some more sensitive compounds don't tolerate the benzyl alcohol preservative well and are better suited to preservative-free sterile water or saline, even though this typically means the reconstituted solution should be used sooner rather than stored for weeks

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In particular, topiramate may control the flow of glutamate and cysteine through System Xc-, which could impact GSH synthesis and improve the ability of GPX4 to change harmful lipid hydroperoxides into safe lipid alcohols

This interaction upregulates the expression of SLC38A2 and SLC7A5 in cancer cells, enhances Gln uptake, and stimulates the expansion and migration of tumor cells