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Valproic acid is a novel activator of AMP-activated protein kinase and decreases liver mass, hepatic fat accumulation, and serum glucose in obese mice

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These drugs are mainly metabolized in the body by the liver and gallbladder, making them suitable for use in elderly patients with diabetes and those with mild to moderate hepatic and renal insufficiency

However, like metformin, thiozonidediones are known to present with various side effects ( Moringa oleifera with antioxidant and anti-inflammatory for their capacity to improve metabolic function in conditions of T2D or metabolic syndrome (Rena et al., 2013

ME: Data curation, Investigation, Visualization, Writing original draft