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Serious Side Effects: In rare cases, semaglutide can cause pancreatitis (inflammation of the pancreas), gallbladder problems, or severe allergic reactions

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These reductions are sustained longer and come with metabolic benefits like improved blood sugar control and reduced cardiovascular inflammation

Key findings across the STEP trials: Average weight loss of ~15% of body weight roughly 15 kg (33 lbs) for a 100 kg (220 lb) person 87% of patients lost at least 5% of body weight, compared to 31% on placebo Nearly 70% of patients lost at least 10% of body weight About 1 in 3 patients lost 20% or more Weight loss was maintained throughout the treatment period with continued medication use Significant improvements in blood pressure, blood sugar, cholesterol, and inflammatory markers alongside weight loss These results are dramatically better than any prior weight loss medication

But the effects of GLP-1 and GIP agonists on facial contours can appear as quickly as the weight disappears