Medicine 83 , 342347 (2004)
It stimulates GH release without significantly elevating cortisol or prolactin (Raun et al., Eur J Endocrinol 1998)
& Helmchen, F
Produced naturally by liver, it is an extremely important molecule concerned with quenching free radicals as well as reduction of oxidative stress and augmentation of immune functions
The antiproliferative effect of calcitriol involves multiple pathways, such as the expression of cyclin-dependent kinase inhibitors (i.e., CDKN1A and CDKN1B), the production of growth factors (i.e., TGF-, IGF) and miRNAs, the regulation of cancer stem cell proliferation, tumor angiogenesis, epithelial-mesenchymal transition, and the activation of caspases (49, 5356)