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IGF-IR also promotes anchorage-independent growth through RACK1-mediated STAT3 and Akt activation [52, 53]

Possible (usually mild) side effects may include: Temporary discomfort or bruising at the injection site Mild headache or nausea in some individuals Rare irritation of the vein (phlebitis) Very rare allergic reactions (screened during pre-treatment assessment) Guided by international clinical standards (Cleveland Clinic, NHS protocols) Serious complications are uncommon when IV infusion therapy is delivered in a controlled clinical setting with appropriate patient selection and monitoring

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Following centrifugation at 2000 g for 10 min at 4 C, serum samples were stored at 80 C 23,32 in aliquots of 50 l in thin wall 0.2 ml PCR tubes arranged in strips of 8 tubes with attached flat lid (Sarstedt, Multiply StripPro)

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