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Clinical Evidence: No IGF-1 Changes Human clinical trials measured serum IGF-1 levels at baseline and throughout treatment with AOD-9604 at various doses

Its three-amino-acid structure (Lys-Pro-Val) allows it to resist proteolytic degradation in the gut lumen, an unusual property that makes it valuable for gastrointestinal inflammation research

Mol Metab 30:72130 Foer D, Beeler PE, Cui J, Karlson EW, Bates DW, Cahill KN (2021) Asthma exacerbations in patients with type 2 diabetes and asthma on Glucagon-like Peptide-1 receptor agonists

This strategy provides both high local concentration and broader systemic support

doi: 10.1038/s41398-024-02902-2