[DOI] [PubMed] [Google Scholar] Davies M, Frch L, Jeppesen OK, Pakseresht A, Pedersen SD, Perreault L, Rosenstock J, Shimomura I, Viljoen A, Wadden TA, Lingvay I & STEP 2 Study Group (2021) Semaglutide 24 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial
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Electrophysiology experiments further demonstrated that GLP-1R activation led to depolarization of POMC neurons and inhibition of NPY/AgRP neurons, mediated by GABAergic signaling, explaining the suppression of hunger signals