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A rapidly acting glutamatergic ARCPVH satiety circuit postsynaptically regulated by -MSH [published correction appears in nat neurosci

GLP-1R agonists represents a novel class of anti-hyperglycemic agent that improve health and survival of -cells (improvement in postprandial hyperglycemia), suppress glucagon (improvement in fasting hyperglycemia), improve insulin resistance (modest effect) and influence energy intake (augment satiety signal) with minimal, if at all, any side effects (weight neutral and non-hypoglycemic)

This isn't a fringe hypothesis it's confirmed mechanistically in peer-reviewed research

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