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There is also substantial evidence that Pg can enter the liver and cause hepatic steatosis ( In contrast, although Fn can also induce intestinal inflammation and changes in the gut microbiota, its impact on TMAO production in healthy individuals under a normal diet is relatively weaker than Pg , possibly due to its less disruptive effect on the intestinal barrier

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Many who declined to participate cited uncertainty regarding costs and the long-term side effects of the drugs