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If considering a dose reduction for maintenance: Wait until weight has stabilized for at least 4 weeks at your current dose Reduce by one dose step (e.g., 12mg to 8mg), do not jump multiple steps Monitor weight closely for 8 weeks after the reduction If weight begins to increase, return to the previous maintenance dose The phase 3 trials specifically tested 4mg as a maintenance dose, suggesting Lilly sees viability in lower maintenance doses What happens if you stop Weight regain after discontinuing GLP-1 agonists is well documented with semaglutide and tirzepatide

Dudman NPB, Wilcken DEL, and Stocker R (1993)

Science (New York, NY) 351 , 728733 (2016)

Screening for potential serum biomarkers in rat mesangial proliferative nephritis

Several pharmaceutical companies have explored transdermal delivery systems to avoid injections, but these formulations have not completed Phase III clinical trials or received FDA clearance