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This endothelial dysfunction impairs microcirculation, meaning the tiny capillaries that deliver oxygen and vital nutrients to the skin become damaged or blocked by microthrombosis (microscopic blood clots)

Fan H, Pan Q, Xu Y, Yang X

Why GLP-1s are Biologically Plausible for Alzheimers Beyond lowering glucose and weight, GLP-1 signaling appears to: Improve insulin signaling in the brain Dampen neuroinflammation (microglial activation) Reduce oxidative stress Interact with amyloid- and tau pathways in preclinical models Recent peer-reviewed reviews synthesize these mechanisms and frame GLP-1s as potential multi-target neuroprotective agents rather than single-pathway drugs

J., Goodpaster, B

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