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A precursor folic acid molecule must interact with the enzyme MTHFR (methylenetetrahydrofolic acid) to become 5-methyltetrahydrofolic acid, the molecule that donates its methyl group to B12 so it can become Methyl-B12

While D64.9 is valid, payers often review it more closely than cause-specific codes like D50.9 (iron deficiency) or D63.1 (anemia in CKD)

PubMed: PMID 30512345

Animal experimental evidence Osteoclast precursor (RAW264.7) experiment: AOD 9604 significantly inhibited RANKL induced osteoclast formation, reduced the number of TRAP positive multinucleated cells, and decreased bone resorption pit formation

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