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The HLCS gene is located on chromosome 21q22.13 and is composed of 19 exons that generate eight alternatively spliced mRNAs, seven of which encode the same 726 amino acid protein (isoform 1) and one which encodes a 873 amino acid protein (isoform 2)

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En cas de traitement par du valproate de sodium (antipileptique) ou de la zidovudine (antiviral, notamment prescrit contre le VIH), qui interfrent avec son mtabolisme 14

In people with ankylosing spondylitis, however, the numbers of interleukin-17-producing cells are higher than normal, leading to excessive inflammation

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