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Individualizing Treatment Goals While weight reduction is a hallmark of GLP-1 therapy, the ideal target varies: Older adults may need more conservative dosing to prevent frailty Patients with polypharmacy or advanced CKD require closer monitoring Ethnicity, comorbidities and baseline weight all influence treatment strategy Personalization remains essential for balancing efficacy and safety

Dual-agonist activation Triggers GLP-1 and GIP simultaneously

NHS England guidance on GLP-1 receptor agonist prescribing

Non-scale victories become apparent improved energy, better sleep, reduced joint pain

The governance layer will be particularly deepened by adopting urban and territorialized approaches to (food) sustainability governance (Cistulli et al., 2014