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Kenfield, M

Its origins in gastric juice foreshadowed its profound ability to maintain gut integrity and orchestrate complex repair processes

Now it's being studied for MS, and psoriatic arthritis, and other autoimmune diseases

29,30 Tryptophan hydroxylase 1, the source of most peripheral 5-HT, is predominantly expressed in the EC cells of the gut and other peripheral tissues, such as the pancreas, lung, and adipose tissue, though is also expressed in the pineal gland where 5-HT serves as the precursor molecule for melatonin biosynthesis

Related enzymes and mechanisms are present in all eukaryotes and most prokaryotes