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To date, conventional Na + or H + ion coupling has yet to be observed in OCTs or OATs, with OCTs thought to function as uniporters rather than symporters, and the OATs coupling the uphill transport of organic anions to the downhill movement of intracellular organic anions, such as -ketoglutarate 25

10.1111/jcmm.15182 40 GuoF.ZhengK.Benede-UbietoR.CuberoF