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84 The topical application of vasodilators provides pain relief in PDPN, suggesting a role for hypoxia and/or vascular dysfunction in the generation of neuropathic pain in DPN

in this case, guidelines recommend an initial dose of 50% basal/50% prandial daily, split over three doses given before meals, with titration as for basal-plus [3]

[54] demonstrated that increased expression of enolase I in human breast cancer patients tumors correlate with increased resistance to tamoxifen