Synthetic SPPS semaglutide has synthesis-related impurities: deletion sequences, amino acid substitution variants, incomplete coupling products, and diastereomers
For most healthy adults, protein intake up to 2g per kg of body weight appears to be safe
Unlike small molecules synthesized in a single step, Semaglutide is first expressed as a precursor or fusion construct, then enzymatically processed with surgical precision to generate the exact therapeutic peptide backbone before any downstream chemical modification takes place
The most common side effects include nausea, digestive discomfort, and appetite changes
Additionally, researchers did not have data on BMI for many participants, which also limits the findings