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Its distinguishing trait is a narrow, clean action on the GH-secretagogue receptor with little activity elsewhere which in the founding pharmacology meant GH went up while cortisol and prolactin stayed near baseline

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The dose-response effect we observed where longer GLP-1 receptor agonist exposure was associated with higher risk strengthens the argument that this association may reflect a true biological effect rather than being due to confounding factors, said study co-author Andrew Mihalache, MD(C), of the Temerty Faculty of Medicine at the University of Toronto, Canada