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In the transgenic APPswePS1dE9 (APP/PS1) mouse model, which stimulates amyloidosis and gliosis, targeting reactive astrocytes improved cognitive function demonstrating their potential for treatment in AD 133

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The briefing materials also noted that it is unclear whether these AEs were attributable to BPC-157

To better understand the role of W33 in small-molecule agonist binding to GLP-1R, we generated the cryo-EM structure of a PF-06882961 analog (PF-06883365) bound to human GLP-1R (Fig

doi: 10.1155/2020/8609213 22 WestIC