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However, native IGF-1's therapeutic utility is significantly limited by its tight binding to a family of six IGF-binding proteins (IGFBPs) that sequester over 99% of circulating IGF-1, creating a reservoir that regulates IGF-1 bioavailability, prolongs its half-life, but drastically restricts the amount of free IGF-1 available to bind and activate cell surface IGF-1 receptors

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A 5-week randomized, double-blind, placebo-controlled trial in 73 participants (ages 21-65) found that L-Carnitine tartrate supplementation (2 g/day elemental L-Carnitine) significantly improved perceived recovery status (p=0.021), lowered serum creatine kinase (p=0.016), and increased superoxide dismutase (SOD) levels, demonstrating enhanced antioxidant capacity

Over 7 in 10 people who had prediabetes at the start of the study had normal blood sugar readings by week 64

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