Genetic deletion or pharmacological inhibition of STING in transgenic mouse models reduced A plaque burden, diminished harmful pro-inflammatory signaling, and protected cognitive function
Risk factors that should prompt consideration of B12 deficiency include advancing age (reduced stomach acid production), strict vegan or vegetarian diets, pernicious anaemia, gastrointestinal surgery (particularly gastric bypass or ileal resection), long-term use of certain medications (metformin, proton pump inhibitors, H2-receptor antagonists), nitrous oxide exposure (including recreational use), and conditions affecting the gut such as Crohn's disease or coeliac disease
Methylmalonic acid and homocysteine testing provide functional assessment of b12 status
Disclaimer: This information is for educational purposes and does not constitute medical advice
Reducing acid output and protecting against acid-induced injury