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doi: 10.1038/s41467-022-28683-0 [DOI] [PMC free article] [PubMed] [Google Scholar] 216.Scheen AJ, Lefbvre PJ

Tirzepatide works by mimicking two incretin hormones (GLP-1 and GIP) to regulate blood sugar, reduce appetite, and slow gastric emptying, leading to: Improved insulin sensitivity Decreased glucagon production Enhanced satiety and reduced cravings Significant weight loss Based on studies Zebpound, Mounjaro , tirzepatide work on the GLP-1 around 44% and GIP receptors in the gut

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22 Mineralocorticoid receptor antagonists (MRA) have also demonstrated clinical benefit in patients with HFpEF