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Complete mortality (100%) occurred in the infected group (IP), whereas the probiotic-fed group (PP) showed a markedly improved survival rate, with mortality reduced to 50% ( P 90% post-processing)

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Petrie MC, Verma S, Docherty KF, Inzucchi SE, Anand I, Belohlavek J, Bohm M, Chiang CE, Chopra VK, de Boer RA, Desai AS, Diez M, Drozdz J, Dukat A, Ge J, Howlett J, Katova T, Kitakaze M, Ljungman CEA, Merkely B, Nicolau JC, OMeara E, Vinh PN, Schou M, Tereshchenko S, Kober L, Kosiborod MN, Langkilde AM, Martinez FA, Ponikowski P, Sabatine MS, Sjostrand M, Solomon SD, Johanson P, Greasley PJ, Boulton D, Bengtsson O, Jhund PS, McMurray JJV

135 In addition to triggering the MCT1/NF-B/IL-8 pathway, it was also found that lactate promotes angiogenesis by stimulating the phosphoinositide 3-kinase/protein kinase B signaling (PI3K/Akt) pathway