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A pivotal study by Germain et al

Red blood cell breakdown (also known as hemolysis) in G6PD deficiency can manifest in many ways, including the following: Prolonged neonatal jaundice, possibly leading to kernicterus (arguably the most serious complication of G6PD deficiency) Hemolytic crises in response to: Illness (especially infections) Certain drugs (see below) Certain foods, most notably broad beans, from which the word favism derives Certain chemicals Diabetic ketoacidosis Hemoglobinuria (red or brown urine) Very severe crisis can cause acute kidney injury Favism is a hemolytic response to the consumption of fava beans, also known as broad beans

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Alternatively, pro-oxidant agents or metabolic inhibitors can further elevate ROS levels, tipping the redox balance toward cell death [32]

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