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The incidence of this side effect is more common among patients with systemic lupus erythematosus or other diseases of the connective tissue, although it has also occurred in patients without these underlying conditions

doi: 10.3389/fcell.2022.999322 Received 20 July 2022 Accepted 23 September 2022 Published 10 October 2022 Volume 10 - 2022 Edited by Maciej Gagat, Nicolaus Copernicus University, Poland Reviewed by John Svaren, University of Wisconsin-Madison, United States Michela Rigoni, University of Padua, Italy Updates Copyright 2022 Klymenko and Lutz

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The peptide may also improve fat oxidation, helping the body preferentially burn fat stores during weight loss

These mediators promote extracellular matrix remodeling, vascular activation, and further immune recruitment, creating a self-sustaining inflammatory niche that facilitates OA progression (Wang B