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Interestingly, Gro3P accumulation caused by loss of solute carrier transporter SLC25A13, which leads to Citrin deficiency, was found to directly activate the transcription factor ChREBP to induce expression of fibroblast growth factor 21 (FGF21), which modulates food and alcohol preferences in the brain and contributes to metabolic dysfunction-associated steatotic liver disease (MASLD)[formerly known as non-alcoholic fatty liver disease (NAFLD)] 19
Nonetheless, multiple sources of bias likely influenced results, including exposure misclassification (es., current shift status used as proxy for lifetime exposure), survivor bias and left truncation in cohorts, and incomplete control for reproductive or behavioral confounders 276
doi: 10.31080/ASAG.2019.03.0683
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